The Lee Laboratory uses emerging biotechnologies to discover and design new approaches to cardiovascular diseases. A central theme of our laboratory is that merging bioengineering and molecular biology approaches can yield novel approaches. Thus, we work at this interface using a broad variety of techniques in genomics, imaging, nanotechnology, physiology, cell biology, and molecular biology. Our approach is to understand problems and design solutions in the laboratory and then demonstrate the effectiveness of these solutions in vivo. Ongoing projects in the laboratory include studies of cardiac regeneration, diabetic vascular disease, wound healing, heart failure, and cardiac hypertrophy.
Recent Publications
Kakkar R, Lee RT. The IL-33 / ST2 pathway: Therapeutic target and novel biomarker. Nature Reviews Drug Discovery 2008;in press.
Patwari P, Lee RT. Mechanical Control of Tissue Morphogenesis. Circ Res 2008;103:234-43.
Sabatine MS, Morrow DA, Higgins LJ, MacGillivray C, Guo W, Bode C, Rifai N, Cannon CP, Gerszten RE, Lee RT. Complementary Roles for Biomarkers of Biomechanical Strain, ST2 and NT-proBNP, in Patients with ST-Elevation Myocardial Infarction. Circulation 2008;117:1936-44.
Tokunou T, Miller R, Patwari P, Davis ME, Segers VFM, Grodzinsky AJ, Lee RT. Engineering Insulin-like Growth Factor-1 for Local Delivery. FASEB J 2008 2008;22:1886-93.
Segers VFM, Lee RT. Stem Cell Therapy for Cardiac Disease. Nature 2008;451:937-942.
Chutkow WA*, Patwari P*, Yoshioka Y, Lee RT. Txnip Is A Critical Regulator of Hepatic Glucose Production. J Biol Chem 2007; 283:2397-406. *equal contributors
Yoshioka J, Imahashi K, Gabel SA, Chutkow WA, Burds AA, Gannon J, Schulze PC, MacGillivray C, London RE, Murphy E, Lee RT. Targeted Deletion of Thioredoxin-Interacting Protein Regulates Cardiac Dysfunction in Response to Pressure Overload. Circ Res 2007;101:1328-38.
Segers VFM, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT. Local Delivery of Protease Resistant SDF-1 for Stem Cell Recruitment after Myocardial Infarction. Circulation 2007;116:1683-92.
Lammerding J, Lee RT. Torn apart: membrane rupture in muscular dystrophies and associated cardiomyopathies. J Clin Invest 2007;117:1749-1752.
Hsieh PCH*, Segers VFM*, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins F, Lee RT. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes following injury. Nature Medicine 2007; 13:970-974. *equal contributors
Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C, Schulze PC, Mazzini MJ, Jensen CB, Krook A, Bjornholm M, Tornqvist H, Zierath JR, Ridderstrale M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK. Txnip is a Marker and Regulator of Peripheral Glucose Homeostasis in Humans. PLOS Medicine 2007; May 1;4:e158.
Sanada S, Hakuno D, Higgins LJ, Schreiter ER, McKenzie AN, Lee RT. IL-33/ST2 is a Critical Biomechanically-induced and Cardioprotective Signaling System. J Clin Invest 2007;117:1538-1549.